Iron and calcium in the central nervous system: A close relationship in health and sickness

Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi

doi:10.1042/BST0361309

Iron and calcium in the central nervous system: A close relationship in health and sickness

Ilaria Pelizzoni, Romina Macco, Daniele Zacchetti, Fabio Grohovaz, Franca Codazzi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative-antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation.

Original language	English
Pages (from-to)	1309-1312
Number of pages	4
Journal	Biochemical Society Transactions
Volume	36
Issue number	6
DOIs	https://doi.org/10.1042/BST0361309
Publication status	Published - 2008

Keywords

Calcium
Iron
Neurodegeneration
Non-transferrin-bound iron (NTBI)
Oxidative stress

ASJC Scopus subject areas

Biochemistry

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10.1042/BST0361309

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abstract = "Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative-antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation.",

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T2 - A close relationship in health and sickness

AU - Pelizzoni, Ilaria

AU - Macco, Romina

AU - Zacchetti, Daniele

AU - Grohovaz, Fabio

AU - Codazzi, Franca

PY - 2008

Y1 - 2008

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AB - Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative-antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation.

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KW - Iron

KW - Neurodegeneration

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KW - Oxidative stress

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Iron and calcium in the central nervous system: A close relationship in health and sickness

Abstract

Keywords

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