TY - JOUR
T1 - Introducing the Jacobian-volume-histogram of deforming organs
T2 - Application to parotid shrinkage evaluation
AU - Fiorino, Claudio
AU - Maggiulli, Eleonora
AU - Broggi, Sara
AU - Liberini, Simone
AU - Cattaneo, Giovanni Mauro
AU - Dell'Oca, Italo
AU - Faggiano, Elena
AU - Di Muzio, Nadia
AU - Calandrino, Riccardo
AU - Rizzo, Giovanna
PY - 2011/6/7
Y1 - 2011/6/7
N2 - The Jacobian of the deformation field of elastic registration between images taken during radiotherapy is a measure of inter-fraction local deformation. The histogram of the Jacobian values (Jac) within an organ was introduced (JVH - Jacobian-volume-histogram) and first applied in quantifying parotid shrinkage. MVCTs of 32 patients previously treated with helical tomotherapy for head-neck cancers were collected. Parotid deformation was evaluated through elastic registration between MVCTs taken at the first and last fractions. Jac was calculated for each voxel of all parotids, and integral JVHs were calculated for each parotid; the correlation between the JVH and the planning dose-volume histogram (DVH) was investigated. On average, 82% (±17%) of the voxels shrinks (Jac <1) and 14% (±17%) shows a local compression >50% (Jac <0.5). The best correlation between the DVH and the JVH was found between V10 and V15, and Jac <0.4-0.6 (p <0.01). The best constraint predicting a higher number of largely compressing voxels (Jac0.5
AB - The Jacobian of the deformation field of elastic registration between images taken during radiotherapy is a measure of inter-fraction local deformation. The histogram of the Jacobian values (Jac) within an organ was introduced (JVH - Jacobian-volume-histogram) and first applied in quantifying parotid shrinkage. MVCTs of 32 patients previously treated with helical tomotherapy for head-neck cancers were collected. Parotid deformation was evaluated through elastic registration between MVCTs taken at the first and last fractions. Jac was calculated for each voxel of all parotids, and integral JVHs were calculated for each parotid; the correlation between the JVH and the planning dose-volume histogram (DVH) was investigated. On average, 82% (±17%) of the voxels shrinks (Jac <1) and 14% (±17%) shows a local compression >50% (Jac <0.5). The best correlation between the DVH and the JVH was found between V10 and V15, and Jac <0.4-0.6 (p <0.01). The best constraint predicting a higher number of largely compressing voxels (Jac0.5
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U2 - 10.1088/0031-9155/56/11/008
DO - 10.1088/0031-9155/56/11/008
M3 - Article
C2 - 21558590
AN - SCOPUS:79956161733
SN - 0031-9155
VL - 56
SP - 3301
EP - 3312
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 11
ER -