Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects

D. Boeri; L. E. Derchi; C. Martinoli; G. Simoni; L. Sampietro; D. Storace; L. Ponte; C. Calvi; M. Repetto; C. Robaudo; M. Maiello

doi:10.1007/s001250050877

Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects

D. Boeri, L. E. Derchi, C. Martinoli, G. Simoni, L. Sampietro, D. Storace, L. Ponte, C. Calvi, M. Repetto, C. Robaudo, M. Maiello

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p <0.002). Kidney volume and resistive index correlated with age (p <0.004), body mass index (p 1 (p

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	Diabetologia
Volume	41
Issue number	1
DOIs	https://doi.org/10.1007/s001250050877
Publication status	Published - 1998

Keywords

Albuminuria
Arteriosclerosis
Duplex Doppler ultrasonography
Kidney
Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/s001250050877

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title = "Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects",

abstract = "It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p <0.002). Kidney volume and resistive index correlated with age (p <0.004), body mass index (p 1 (p",

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author = "D. Boeri and Derchi, {L. E.} and C. Martinoli and G. Simoni and L. Sampietro and D. Storace and L. Ponte and C. Calvi and M. Repetto and C. Robaudo and M. Maiello",

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AU - Boeri, D.

AU - Derchi, L. E.

AU - Martinoli, C.

AU - Simoni, G.

AU - Sampietro, L.

AU - Storace, D.

AU - Ponte, L.

AU - Calvi, C.

AU - Repetto, M.

AU - Robaudo, C.

AU - Maiello, M.

PY - 1998

Y1 - 1998

N2 - It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p <0.002). Kidney volume and resistive index correlated with age (p <0.004), body mass index (p 1 (p

AB - It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p <0.002). Kidney volume and resistive index correlated with age (p <0.004), body mass index (p 1 (p

KW - Albuminuria

KW - Arteriosclerosis

KW - Duplex Doppler ultrasonography

KW - Kidney

KW - Non-insulin-dependent diabetes mellitus

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Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects

Abstract

Keywords

ASJC Scopus subject areas

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