TY - JOUR
T1 - Intraoperative radiotherapy during breast conserving surgery
T2 - A study on 1,822 cases treated with electrons
AU - Veronesi, Umberto
AU - Orecchia, Roberto
AU - Luini, Alberto
AU - Galimberti, Viviana
AU - Zurrida, Stefano
AU - Intra, Mattia
AU - Veronesi, Paolo
AU - Arnone, Paolo
AU - Leonardi, Maria Cristina
AU - Ciocca, Mario
AU - Lazzari, Roberta
AU - Caldarella, Pietro
AU - Rotmensz, Nicole
AU - Sangalli, Claudia
AU - Sances, Daniele
AU - Maisonneuve, Patrick
PY - 2010/11
Y1 - 2010/11
N2 - Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2%) and fibrosis (1.8%). After a mean follow-up of 36.1 months, 42 women (2.3%) developed a local recurrence, 24 (1.3%) a new primary ipsilateral carcinomas and 26 (1.4%) distant metastases as first event. Forty-six women died (2.5%), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.
AB - Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2%) and fibrosis (1.8%). After a mean follow-up of 36.1 months, 42 women (2.3%) developed a local recurrence, 24 (1.3%) a new primary ipsilateral carcinomas and 26 (1.4%) distant metastases as first event. Forty-six women died (2.5%), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.
KW - Breast cancer
KW - Conserving surgery
KW - Intraoperative radiotherapy
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U2 - 10.1007/s10549-010-1115-5
DO - 10.1007/s10549-010-1115-5
M3 - Article
C2 - 20711810
AN - SCOPUS:77957717073
SN - 0167-6806
VL - 124
SP - 141
EP - 151
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -