Intramolecular lactones of sialic acids

Paola Rota, Paolo La Rocca, Pietro Allevi, Carlo Pappone, Luigi Anastasia

Research output: Contribution to journalReview articlepeer-review


The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes. The intramolecular lactones of sialic acids are a subclass from this crucial family that could have central functions in the discrimination of physiological and pathological conditions. In this review, we report an in-depth analysis of the synthetic achievements in the preparation of the intramolecular lactones of sialic acids (1,4-, 1,7-and γ-lactones), in their free and/or protected form. In particular, recent advances in the synthesis of the 1,7-lactones have allowed the preparation of key sialic acid derivatives. These compounds could be used as authentic reference standards for their correct determination in biological samples, thus overcoming some of the limitations of the previous analytical procedures.

Original languageEnglish
Article number8098
Pages (from-to)1-25
Number of pages25
JournalInternational Journal of Molecular Sciences
Issue number21
Publication statusPublished - Nov 1 2020


  • Biomarker
  • Heptafluoro derivatives
  • Lactone
  • Sialic acid
  • Tumor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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