Intralesional (incision) biopsy for melanoma diagnosis: The rules and the exception

Elvira Moscarella, Giuseppe Argenziano, Claudia Moreno, Simonetta Piana, Aimilios Lallas, Mara Lombardi, Caterina Longo, Gerardo Ferrara

Research output: Contribution to journalArticlepeer-review


Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for those lesions whose in-toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, traumatic skin changes, and nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.

Original languageEnglish
Pages (from-to)658-662
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number6
Publication statusPublished - Dec 1 2017


  • Biopsy
  • Dermoscopy
  • Histology
  • Melanoma
  • Skin diseases

ASJC Scopus subject areas

  • Dermatology


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