Intradural pediatric spinal tumors: An overview from imaging to novel molecular findings

Antonio Marrazzo, Antonella Cacchione, Sabrina Rossi, Alessia Carboni, Carlo Gandolfo, Andrea Carai, Angela Mastronuzzi, Giovanna Stefania Colafati

Research output: Contribution to journalReview articlepeer-review


Pediatric spinal tumors are rare and account for 10% of all central nervous system tumors in children. Onset usually occurs with chronic nonspecific symptoms and may depend on the intra-or extradural neoplastic location. Meningiomas, schwannomas, and neurofibromas are the most common intradural-extramedullary lesions, while astrocytomas and ependymomas represent the majority of intramedullary tumors. The new molecular discoveries regarding pediatric spinal cancer currently contribute to the diagnostic and therapeutic processes. Moreover, some familial genetic syndromes can be associated with the development of spinal tumors. Currently, magnetic resonance imaging (MRI) is the standard reference for the evaluation of pediatric spinal tumors. Our aim in this review was to describe the imaging of the most frequent intradural intra/extramedullary pediatric spinal tumors and to investigate the latest molecular findings and genetic syndromes.

Original languageEnglish
Article number1710
Issue number9
Publication statusPublished - Sept 2021


  • Cancer predisposition syndromes
  • Children
  • Spine tumor

ASJC Scopus subject areas

  • Clinical Biochemistry


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