Intraductal injection of neoprene to suppress native pancreatic exocrine secretion in humans: Clinical and metabolic evaluation

The management of exocrine pancreatic secretion represents an important technical problem in human segmental pancreatic transplantation. Among other methods, the suppression of exocrine secretion by duct injection with polymers is currently a widely accepted technique. Fibrosis induced by injected agents might be a possible cause of graft failure. In this report, we present metabolic data concerning endocrine pancreatic function in patients subjected to pancreaticoduodenectomy because of inflammatory or malignant diseases and injection of neoprene into the pancreatic duct to inhibit exocrine secretion from the residual pancreas. This procedure was used to avoid life-threatening complications that often occur after a pancreatico-digestive anastomosis.