Intracranial venous haemodynamics in multiple sclerosis

Paolo Zamboni, Erica Menegatti, Ilaria Bartolomei, Roberto Galeotti, Anna Maria Malagoni, Giovanna Tacconi, Fabrizio Salvi

Research output: Contribution to journalArticlepeer-review


In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p

Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalCurrent Neurovascular Research
Issue number4
Publication statusPublished - Nov 2007


  • Cerebral veins
  • Multiple sclerosis
  • Transcranial color-coded duplex sonography
  • Venous haemodynamics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Intracranial venous haemodynamics in multiple sclerosis'. Together they form a unique fingerprint.

Cite this