TY - JOUR
T1 - Intracranial venous haemodynamics in multiple sclerosis
AU - Zamboni, Paolo
AU - Menegatti, Erica
AU - Bartolomei, Ilaria
AU - Galeotti, Roberto
AU - Malagoni, Anna Maria
AU - Tacconi, Giovanna
AU - Salvi, Fabrizio
PY - 2007/11
Y1 - 2007/11
N2 - In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p
AB - In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. -1.3 ±2.6 cm/sec in MS, respectively, p
KW - Cerebral veins
KW - Multiple sclerosis
KW - Transcranial color-coded duplex sonography
KW - Venous haemodynamics
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U2 - 10.2174/156720207782446298
DO - 10.2174/156720207782446298
M3 - Article
C2 - 18045150
AN - SCOPUS:36448997799
SN - 1567-2026
VL - 4
SP - 252
EP - 258
JO - Current Neurovascular Research
JF - Current Neurovascular Research
IS - 4
ER -