TY - JOUR
T1 - Intra-hepatic messenger RNA levels for interferons and related genes in hepatitis C virus/HIV co-infected patients
AU - Abbate, Isabella
AU - Cappiello, Giuseppina
AU - Rosati, Silvia
AU - Tocci, Guido
AU - Antonucci, Giorgio
AU - Solmone, Mariacarmela
AU - Longo, Roberta
AU - Spanò, Alberto
AU - Capobianchi, Maria Rosaria
PY - 2004/3/5
Y1 - 2004/3/5
N2 - Intra-hepatic levels of mRNA for IFN-α, IFN-γ, IFN type 1 receptor (IFNAR-1) and PKR were determined in hepatitis C virus (HCV)/HIV co-infected and HCV mono-infected patients. In co-infected patients, IFN-α mRNA was upregulated and correlated with HIV-1 viraemia. IFN-γ, IFNAR-1 and PKR mRNA were detected in mono-infected, but not in co-infected patients. These findings suggest that in HCV/HIV co-infected individuals the ability to respond to IFN-α is impaired, probably because of the absence of its receptor.
AB - Intra-hepatic levels of mRNA for IFN-α, IFN-γ, IFN type 1 receptor (IFNAR-1) and PKR were determined in hepatitis C virus (HCV)/HIV co-infected and HCV mono-infected patients. In co-infected patients, IFN-α mRNA was upregulated and correlated with HIV-1 viraemia. IFN-γ, IFNAR-1 and PKR mRNA were detected in mono-infected, but not in co-infected patients. These findings suggest that in HCV/HIV co-infected individuals the ability to respond to IFN-α is impaired, probably because of the absence of its receptor.
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U2 - 10.1097/00002030-200403050-00015
DO - 10.1097/00002030-200403050-00015
M3 - Article
C2 - 15090776
AN - SCOPUS:1642354762
SN - 0269-9370
VL - 18
SP - 691
EP - 692
JO - AIDS
JF - AIDS
IS - 4
ER -