Intestinal Calcium Absorption among Hypercalciuric Patients with or without Calcium Kidney Stones

G. Vezzoli, Lorenza Macrina, A. Rubinacci, D. Spotti, T. Arcidiacono

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND OBJECTIVES: Idiopathic hypercalciuria is a frequent defect in calcium kidney stone formers that is associated with high intestinal calcium absorption and osteopenia. Characteristics distinguishing hypercalciuric stone formers from hypercalciuric patients without kidney stone history (HNSFs) are unknown and were explored in our study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We compared 172 hypercalciuric stone formers with 36 HNSFs retrospectively selected from patients referred to outpatient clinics of the San Raffaele Hospital in Milan from 1998 to 2003. Calcium metabolism and lumbar bone mineral density were analyzed in these patients. A strontium oral load test was performed: strontium was measured in 240-minute urine and serum 30, 60, and 240 minutes after strontium ingestion; serum strontium concentration-time curve and renal strontium clearance were evaluated to estimate absorption and excretion of divalent cations. RESULTS: Serum strontium concentration-time curve (P
Original languageEnglish
Pages (from-to)1450-1455
Number of pages6
JournalClinical journal of the American Society of Nephrology : CJASN
Issue number8
Publication statusPublished - 2016


  • Bone Density
  • Bone Diseases, Metabolic
  • Calcium, Dietary
  • Humans
  • Intestinal Absorption
  • Regression Analysis
  • Strontium
  • calcium metabolism disorders
  • hypercalciuria
  • kidney stones


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