Intermittent and persistent allergic rhinitis and association with asthma in children

Giorgio Ciprandi, G. Cadario, M. Di Gioacchino, M. A. Tosca, R. Bernardini, G. L. Marseglia, S. Gangemi, S. Isola, F. Marengo, M. Minelli, L. Ricciardi, E. Ridolo, C. Valle, M. Verini, P. Borrelli, E. Varin, R. Sambugaro, P. Puccinelli, C. Incorvaia, M. RusselloM. Milioni, R. Boccardo, E. Piergentili, A. Di Rienzo, F. Frati

Research output: Contribution to journalArticlepeer-review


The natural history of allergic rhinitis (AR) is commonly characterized by worsening of symptom severity, frequent comorbidity with asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts in early childhood. AR classification has been recently revised, and some studies investigated the new types: intermittent (IAR) and persistent (PER) AR. However, no study has been carried out on children regarding this issue. This preliminary study was performed on a large cohort of children with allergic rhinitis to evaluate the type and severity of rhinitis and its possible association with asthma, including severity grade. One hundred and thirty-nine children (86 males, 53 females, mean age 11.8 years, range 3.5-17.7 years) with allergic rhinitis were prospectively and consecutively evaluated. Seventy-one children had rhinitis alone and 68 had rhinitis associated with asthma. Forty children had IAR, 30 of whom with moderate-severe grade. Ninety-nine children had PER, 65 of whom had moderate-severe grade. The Severity of AR was not associated with asthma presence (Fisher X2 = 0.5765; Prob.=0.9018). Regarding asthma severity, 30 children had the intermittent form, whereas 38 had the persistent form: 15 mild, 22 moderate, and 1 severe. This study provides the first evidence concerning the ARIA classification in children, partially confirming findings obtained in adulthood.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalEuropean Journal of Inflammation
Issue number3
Publication statusPublished - Sept 2008


  • Allergic rhinitis classification and severity
  • ARIA
  • Asthma
  • Children

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


Dive into the research topics of 'Intermittent and persistent allergic rhinitis and association with asthma in children'. Together they form a unique fingerprint.

Cite this