TY - JOUR
T1 - Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae
AU - Sironi, Marina
AU - Sica, Antonio
AU - Riganti, Franca
AU - Licciardello, Luciano
AU - Colotta, Francesco
AU - Mantovani, Alberto
PY - 1990
Y1 - 1990
N2 - The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.
AB - The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.
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U2 - 10.1016/0192-0561(90)90021-E
DO - 10.1016/0192-0561(90)90021-E
M3 - Article
C2 - 2202691
AN - SCOPUS:0025373203
SN - 0192-0561
VL - 12
SP - 397
EP - 402
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
IS - 4
ER -