TY - JOUR
T1 - Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma
AU - Bergui, L.
AU - Schena, M.
AU - Gaidano, G.
AU - Riva, M.
AU - Caligaris-Cappio, F.
PY - 1989
Y1 - 1989
N2 - PBMC from 11 patients with multiple myeloma (MM) were cultured in vitro in presence of IL-3 and IL-6. After 3 d, actively proliferating immunoblast-like B cells (20-62%) were apparent. After 6 d, a population of morphologically evident plasma cells was observed (30-50%) that expressed, in each individual case, the same light and heavy chain produced by bone marrow malignant plasma cells. We conclude that in MM the malignant plasma cell precursors are circulating and their growth and terminal differentiation are under the synergistic control of IL-3 and IL-6.
AB - PBMC from 11 patients with multiple myeloma (MM) were cultured in vitro in presence of IL-3 and IL-6. After 3 d, actively proliferating immunoblast-like B cells (20-62%) were apparent. After 6 d, a population of morphologically evident plasma cells was observed (30-50%) that expressed, in each individual case, the same light and heavy chain produced by bone marrow malignant plasma cells. We conclude that in MM the malignant plasma cell precursors are circulating and their growth and terminal differentiation are under the synergistic control of IL-3 and IL-6.
UR - http://www.scopus.com/inward/record.url?scp=0024365825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024365825&partnerID=8YFLogxK
M3 - Article
C2 - 2787832
AN - SCOPUS:0024365825
SN - 0022-1007
VL - 170
SP - 613
EP - 618
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -