Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

Sabrina Stanzione; Guido Cimoli; Domizia Debernardis; Andrea Michelotti; PierFranco Conte; Silvio Parodi; Patrizia Russo

doi:10.1016/0165-7992(95)00057-7

Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

Sabrina Stanzione, Guido Cimoli, Domizia Debernardis, Andrea Michelotti, PierFranco Conte, Silvio Parodi, Patrizia Russo

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.

Original language	English
Pages (from-to)	131-135
Number of pages	5
Journal	Mutation Research Letters
Volume	348
Issue number	3
DOIs	https://doi.org/10.1016/0165-7992(95)00057-7
Publication status	Published - 1995

Keywords

DNA damage
Glioman
Interferons
Platinum
Potentiation

ASJC Scopus subject areas

Genetics
Toxicology

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10.1016/0165-7992(95)00057-7

Cite this

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title = "Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines",

abstract = "The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.",

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T1 - Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

AU - Stanzione, Sabrina

AU - Cimoli, Guido

AU - Debernardis, Domizia

AU - Michelotti, Andrea

AU - Conte, PierFranco

AU - Parodi, Silvio

AU - Russo, Patrizia

PY - 1995

Y1 - 1995

N2 - The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.

AB - The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.

KW - DNA damage

KW - Glioman

KW - Interferons

KW - Platinum

KW - Potentiation

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Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

Abstract

Keywords

ASJC Scopus subject areas

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