Interest of combined blood pressure measurements in very old frail subjects: The partage study

Jean Jacques Mourad, Davide Agnoletti, Carlos Labat, Sylvie Gautier, Paolo Salvi, Filippo Valbusa, Olivier Hanon, Olivier Toulza, Patrick Manckoundia, Francesco Fantin, Yves Rolland, Athanase Benetos

Research output: Contribution to journalArticlepeer-review


BACKGROUND Several clinical studies have shown that blood pressure (BP) measurements in very old frail individuals are of limited interest due to the fact that several age-related alterations and geriatric syndromes may modify BP. We studied in persons over 80-year old living in nursing homes the combined effects of 3 BP patterns on total mortality and major cardiovascular (CV) events: (i) low pulse pressure amplification (L-PPA) between carotid and brachial artery, (ii) systolic BP (SBP) <130 mm Hg (L-SBP), under >1 antihypertensive drugs, and (iii) changes in SBP between supine and upright position of >20 mm Hg in both directions (hypotension/hypertension, orthostatic SBP [O-SBP]). METHODS This analysis was performed in subjects of the PARTAGE study presenting all these 3 measurements (n = 883). The combined effects of L-PPA, L-SBP, and O-SBP were studied during the 2 years followed-up period. RESULTS After adjusting for age, sex, and history of CV events, all 3 BP patterns were independent determinants of major CV events (L-PPA, (P = 0.023); L-SBP, (P = 0.050); O-SBP, (P = 0.015)), whereas L-PPA (P = 0.012) and L-SBP (P = 0.006) were also independent determinants of total mortality. Compared with the subjects without any BP pattern, the presence of 2 or 3 BP patterns was associated with an increase in total mortality and major CV events greater than 2 and 2.5 times, respectively. CONCLUSIONS In very old frail subjects, there is a particular interest for using different BP measurement approaches, than in younger populations, in order to evaluate the risks related to the BP levels. CLINICAL TRIALS REGISTRATION Trial Number: NCT00901355 (Clinical

Original languageEnglish
Pages (from-to)950-956
Number of pages7
JournalAmerican Journal of Hypertension
Issue number8
Publication statusPublished - Jul 16 2018


  • antihypertensive drugs
  • blood pressure
  • frailty
  • hypertension
  • mortality
  • orthostatic hypertension
  • orthostatic hypotension
  • pulse pressure amplification

ASJC Scopus subject areas

  • Internal Medicine


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