Intercellular Ca2+ waves sustain coordinate insulin secretion in pig islets of Langerhans

F. Bertuzzi, D. Zacchetti, C. Berra, C. Socci, G. Pozza, A. E. Pontiroli, F. Grohovaz

Research output: Contribution to journalArticlepeer-review


Insulin release was investigated in parallel with changes in cytosolic calcium concentration, [Ca2+]i, in pig islets stimulated by glucose. After two days in culture, glucose stimulation failed to induce insulin release, and caused limited [Ca2+]i changes in few cells. After ten days, insulin response was partially restored and [Ca2+]i recordings revealed a slow oscillatory activity of the whole islet. Slow oscillations appeared to be due to the average [Ca2+]i variations resulting from the spreading of waves throughout the islet. These waves demonstrate the reestablishment of functional cell coupling, which appears to play a critical role in insulin release.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalFEBS Letters
Issue number1
Publication statusPublished - Jan 22 1996


  • Ca oscillation
  • Ca wave
  • Fura-2
  • Insulin secretion
  • Islets of Langerhans

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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