Interaction of Sr-doped hydroxy apatite nanocrystals with osteoclast and osteoblast-like cells

C. Capuccini, P. Torricelli, E. Boanini, M. Gazzano, R. Giardino, A. Bigi

Research output: Contribution to journalArticlepeer-review


This article reports the effect of strontium incorporation into hydroxyapatite nanocrystals on bone cells response. Hydroxyapatite nanocrystals were synthesized at strontium contents of 0, 1, 3, 7 atom %. Strontium incorporation for calcium is confirmed by the linear increase of the unit cell parameters of hydroxyapatite, in agreement with the different ionic radii of the two ions. Moreover, strontium substitution slightly affects hydroxyapatite structural order and the shape of the nanocrystals. Osteoblast-like MG63 cells cultured on the nanocrystals display good proliferation and increased values of the differentiation parameters. In particular, when cultured on samples with Sr conentration in the range 3-7 atom %, osteoblasts display increased values of ALP activity, collagen type I, and osteocalcin production. Moreover, the osteoclast number on all the Sr-doped samples is significantly smaller than on hydroxyapatite, and it decreases on increasing strontium content. The data indicate that strontium stimulates osteoblast activity and exerts its inhibitory effect on osteoclast proliferation even when incorporated into hydroxyapatite.

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Issue number3
Publication statusPublished - Jun 1 2009


  • Hydroxyapatite
  • Osteoblast
  • Osteoclast
  • Strontium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys


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