Interaction of hemoglobin with hydrogen ions, carbon dioxide, and organic phosphates

Recent work on the reactions and interactions of oxygen linked ligands, especially those related to the physiological functions of mammalian hemoglobin are summarized. The review does not aim to be comprehensive; rather, it is centered more on presenting some of the basic experimental facts and the development of interpretations based mainly on the molecular structure. Some of the material presented is for the purpose of simplifying and connecting the various parts, although not yet fully reported. It should be stressed that authors tend to emphasize their own approach to the problems; where interpretations are controversial, those most consistent with structural evidence were favored.