Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

A Gupta; VR Taqueti; TP van de Hoef; NS Bajaj; PE Bravo; VL Murthy; MT Osborne; SB Seidelmann; T Vita; CF Bibbo; M Harrington; J Hainer; O Rimoldi; S Dorbala; DL Bhatt; R Blankstein; PG Camici; MF Di Carli

doi:10.1161/CIRCULATIONAHA.117.029992

Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

A Gupta, VR Taqueti, TP van de Hoef, NS Bajaj, PE Bravo, VL Murthy, MT Osborne, SB Seidelmann, T Vita, CF Bibbo, M Harrington, J Hainer, O Rimoldi, S Dorbala, DL Bhatt, R Blankstein, PG Camici, MF Di Carli

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows for comprehensive evaluation of patients with known or suspected stable coronary artery disease. Because management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. METHODS: MBF and CFR were quantified in 4029 consecutive patients (median age 66 years, 50.5% women) referred for rest/stress myocardial perfusion positron emission tomography scans from January 2006 to December 2013. The primary outcome was cardiovascular mortality. Maximal MBF

Original language	English
Pages (from-to)	2325-2336
Number of pages	12
Journal	Circulation
Volume	136
Issue number	24
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.117.029992
Publication status	Published - 2017

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10.1161/CIRCULATIONAHA.117.029992

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Gupta, A., Taqueti, VR., van de Hoef, TP., Bajaj, NS., Bravo, PE., Murthy, VL., Osborne, MT., Seidelmann, SB., Vita, T., Bibbo, CF., Harrington, M., Hainer, J., Rimoldi, O., Dorbala, S., Bhatt, DL., Blankstein, R., Camici, PG., & Di Carli, MF. (2017). Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease. Circulation, 136(24), 2325-2336. https://doi.org/10.1161/CIRCULATIONAHA.117.029992

Gupta, A, Taqueti, VR, van de Hoef, TP, Bajaj, NS, Bravo, PE, Murthy, VL, Osborne, MT, Seidelmann, SB, Vita, T, Bibbo, CF, Harrington, M, Hainer, J, Rimoldi, O, Dorbala, S, Bhatt, DL, Blankstein, R, Camici, PG & Di Carli, MF 2017, 'Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease', Circulation, vol. 136, no. 24, pp. 2325-2336. https://doi.org/10.1161/CIRCULATIONAHA.117.029992

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title = "Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease",

abstract = "BACKGROUND: It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows for comprehensive evaluation of patients with known or suspected stable coronary artery disease. Because management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. METHODS: MBF and CFR were quantified in 4029 consecutive patients (median age 66 years, 50.5% women) referred for rest/stress myocardial perfusion positron emission tomography scans from January 2006 to December 2013. The primary outcome was cardiovascular mortality. Maximal MBF ",

author = "A Gupta and VR Taqueti and {van de Hoef}, TP and NS Bajaj and PE Bravo and VL Murthy and MT Osborne and SB Seidelmann and T Vita and CF Bibbo and M Harrington and J Hainer and O Rimoldi and S Dorbala and DL Bhatt and R Blankstein and PG Camici and {Di Carli}, MF",

year = "2017",

doi = "10.1161/CIRCULATIONAHA.117.029992",

language = "English",

volume = "136",

pages = "2325--2336",

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T1 - Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

AU - Gupta, A

AU - Taqueti, VR

AU - van de Hoef, TP

AU - Bajaj, NS

AU - Bravo, PE

AU - Murthy, VL

AU - Osborne, MT

AU - Seidelmann, SB

AU - Vita, T

AU - Bibbo, CF

AU - Harrington, M

AU - Hainer, J

AU - Rimoldi, O

AU - Dorbala, S

AU - Bhatt, DL

AU - Blankstein, R

AU - Camici, PG

AU - Di Carli, MF

PY - 2017

Y1 - 2017

N2 - BACKGROUND: It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows for comprehensive evaluation of patients with known or suspected stable coronary artery disease. Because management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. METHODS: MBF and CFR were quantified in 4029 consecutive patients (median age 66 years, 50.5% women) referred for rest/stress myocardial perfusion positron emission tomography scans from January 2006 to December 2013. The primary outcome was cardiovascular mortality. Maximal MBF

AB - BACKGROUND: It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows for comprehensive evaluation of patients with known or suspected stable coronary artery disease. Because management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. METHODS: MBF and CFR were quantified in 4029 consecutive patients (median age 66 years, 50.5% women) referred for rest/stress myocardial perfusion positron emission tomography scans from January 2006 to December 2013. The primary outcome was cardiovascular mortality. Maximal MBF

U2 - 10.1161/CIRCULATIONAHA.117.029992

DO - 10.1161/CIRCULATIONAHA.117.029992

M3 - Article

SN - 0009-7322

VL - 136

SP - 2325

EP - 2336

JO - Circulation

JF - Circulation

IS - 24

ER -

Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease

Abstract

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