Intact rat liver nuclei catalyze adriamycin irreversible interactions with dna and nuclear proteins

Enrico Garattini; Maria Grazia Donelli; Paolo Catalani; Claudio Pantarotto

doi:10.1016/0378-4274(83)90248-5

Intact rat liver nuclei catalyze adriamycin irreversible interactions with dna and nuclear proteins

Enrico Garattini, Maria Grazia Donelli, Paolo Catalani, Claudio Pantarotto

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Male rat liver intact nuclear preparations are able to metabolize adriamycin to reactive species that irreversibly interact with nuclear DNA and proteins in the presence of reduced NADPH. This process was not inhibited by 1 mM SKF-525A, suggesting that a nuclear monooxygenase enzymatic system was not involved.

Original language	English
Pages (from-to)	343-348
Number of pages	6
Journal	Toxicology Letters
Volume	17
Issue number	3-4
DOIs	https://doi.org/10.1016/0378-4274(83)90248-5
Publication status	Published - 1983

Keywords

Adriamycin
covalent binding
DNA
proteins
rat liver nuclei

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(83)90248-5

Cite this

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title = "Intact rat liver nuclei catalyze adriamycin irreversible interactions with dna and nuclear proteins",

abstract = "Male rat liver intact nuclear preparations are able to metabolize adriamycin to reactive species that irreversibly interact with nuclear DNA and proteins in the presence of reduced NADPH. This process was not inhibited by 1 mM SKF-525A, suggesting that a nuclear monooxygenase enzymatic system was not involved.",

keywords = "Adriamycin, covalent binding, DNA, proteins, rat liver nuclei",

author = "Enrico Garattini and Donelli, {Maria Grazia} and Paolo Catalani and Claudio Pantarotto",

year = "1983",

doi = "10.1016/0378-4274(83)90248-5",

language = "English",

volume = "17",

pages = "343--348",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

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T1 - Intact rat liver nuclei catalyze adriamycin irreversible interactions with dna and nuclear proteins

AU - Garattini, Enrico

AU - Donelli, Maria Grazia

AU - Catalani, Paolo

AU - Pantarotto, Claudio

PY - 1983

Y1 - 1983

N2 - Male rat liver intact nuclear preparations are able to metabolize adriamycin to reactive species that irreversibly interact with nuclear DNA and proteins in the presence of reduced NADPH. This process was not inhibited by 1 mM SKF-525A, suggesting that a nuclear monooxygenase enzymatic system was not involved.

AB - Male rat liver intact nuclear preparations are able to metabolize adriamycin to reactive species that irreversibly interact with nuclear DNA and proteins in the presence of reduced NADPH. This process was not inhibited by 1 mM SKF-525A, suggesting that a nuclear monooxygenase enzymatic system was not involved.

KW - Adriamycin

KW - covalent binding

KW - DNA

KW - proteins

KW - rat liver nuclei

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U2 - 10.1016/0378-4274(83)90248-5

DO - 10.1016/0378-4274(83)90248-5

M3 - Article

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AN - SCOPUS:0020596890

SN - 0378-4274

VL - 17

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EP - 348

JO - Toxicology Letters

JF - Toxicology Letters

IS - 3-4

ER -

Intact rat liver nuclei catalyze adriamycin irreversible interactions with dna and nuclear proteins

Abstract

Keywords

ASJC Scopus subject areas

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