Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort

J. Ose; R. T. Fortner; H. Schock; P. H. Peeters; N. C. Onland-Moret; H. B. Bueno-De-Mesquita; E. Weiderpass; I. T. Gram; K. Overvad; A. Tjonneland; L. Dossus; A. Fournier; L. Baglietto; A. Trichopoulou; V. Benetou; D. Trichopoulos; H. Boeing; G. Masala; V. Krogh; A. Matiello; R. Tumino; M. Popovic; M. Obón-Santacana; N. Larrañaga; E. Ardanaz; M. J. Sánchez; V. Menéndez; M. D. Chirlaque; R. C. Travis; K. T. Khaw; J. Brändstedt; A. Idahl; E. Lundin; S. Rinaldi; E. Kuhn; I. Romieu; M. J. Gunter; M. A. Merritt; E. Riboli; R. Kaaks

doi:10.1038/bjc.2014.566

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort

J. Ose, R. T. Fortner, H. Schock, P. H. Peeters, N. C. Onland-Moret, H. B. Bueno-De-Mesquita, E. Weiderpass, I. T. Gram, K. Overvad, A. Tjonneland, L. Dossus, A. Fournier, L. Baglietto, A. Trichopoulou, V. Benetou, D. Trichopoulos, H. Boeing, G. Masala, V. Krogh, A. MatielloR. Tumino, M. Popovic, M. Obón-Santacana, N. Larrañaga, E. Ardanaz, M. J. Sánchez, V. Menéndez, M. D. Chirlaque, R. C. Travis, K. T. Khaw, J. Brändstedt, A. Idahl, E. Lundin, S. Rinaldi, E. Kuhn, I. Romieu, M. J. Gunter, M. A. Merritt, E. Riboli, R. Kaaks

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Original language	English
Pages (from-to)	162-166
Number of pages	5
Journal	British Journal of Cancer
Volume	112
Issue number	1
DOIs	https://doi.org/10.1038/bjc.2014.566
Publication status	Published - Jan 6 2015

Keywords

carcinogenesis
dualistic pathway
histological subtypes
IGF-I
ovarian cancer
type I/type II

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-De-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., ... Kaaks, R. (2015). Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort. British Journal of Cancer, 112(1), 162-166. https://doi.org/10.1038/bjc.2014.566

Ose, J, Fortner, RT, Schock, H, Peeters, PH, Onland-Moret, NC, Bueno-De-Mesquita, HB, Weiderpass, E, Gram, IT, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E, Sánchez, MJ, Menéndez, V, Chirlaque, MD, Travis, RC, Khaw, KT, Brändstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, MJ, Merritt, MA, Riboli, E & Kaaks, R 2015, 'Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort', British Journal of Cancer, vol. 112, no. 1, pp. 162-166. https://doi.org/10.1038/bjc.2014.566

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title = "Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort",

abstract = "Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.",

keywords = "carcinogenesis, dualistic pathway, histological subtypes, IGF-I, ovarian cancer, type I/type II",

author = "J. Ose and Fortner, {R. T.} and H. Schock and Peeters, {P. H.} and Onland-Moret, {N. C.} and Bueno-De-Mesquita, {H. B.} and E. Weiderpass and Gram, {I. T.} and K. Overvad and A. Tjonneland and L. Dossus and A. Fournier and L. Baglietto and A. Trichopoulou and V. Benetou and D. Trichopoulos and H. Boeing and G. Masala and V. Krogh and A. Matiello and R. Tumino and M. Popovic and M. Ob{\'o}n-Santacana and N. Larra{\~n}aga and E. Ardanaz and S{\'a}nchez, {M. J.} and V. Men{\'e}ndez and Chirlaque, {M. D.} and Travis, {R. C.} and Khaw, {K. T.} and J. Br{\"a}ndstedt and A. Idahl and E. Lundin and S. Rinaldi and E. Kuhn and I. Romieu and Gunter, {M. J.} and Merritt, {M. A.} and E. Riboli and R. Kaaks",

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T2 - Results from the EPIC cohort

AU - Ose, J.

AU - Fortner, R. T.

AU - Schock, H.

AU - Peeters, P. H.

AU - Onland-Moret, N. C.

AU - Bueno-De-Mesquita, H. B.

AU - Weiderpass, E.

AU - Gram, I. T.

AU - Overvad, K.

AU - Tjonneland, A.

AU - Dossus, L.

AU - Fournier, A.

AU - Baglietto, L.

AU - Trichopoulou, A.

AU - Benetou, V.

AU - Trichopoulos, D.

AU - Boeing, H.

AU - Masala, G.

AU - Krogh, V.

AU - Matiello, A.

AU - Tumino, R.

AU - Popovic, M.

AU - Obón-Santacana, M.

AU - Larrañaga, N.

AU - Ardanaz, E.

AU - Sánchez, M. J.

AU - Menéndez, V.

AU - Chirlaque, M. D.

AU - Travis, R. C.

AU - Khaw, K. T.

AU - Brändstedt, J.

AU - Idahl, A.

AU - Lundin, E.

AU - Rinaldi, S.

AU - Kuhn, E.

AU - Romieu, I.

AU - Gunter, M. J.

AU - Merritt, M. A.

AU - Riboli, E.

AU - Kaaks, R.

PY - 2015/1/6

Y1 - 2015/1/6

N2 - Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

AB - Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

KW - carcinogenesis

KW - dualistic pathway

KW - histological subtypes

KW - IGF-I

KW - ovarian cancer

KW - type I/type II

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JF - British Journal of Cancer

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Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort

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Keywords

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