Instability of mitochondrial DNA and MRI and clinical correlations in malignant gliomas

Luisa Montanini, Caroline Regna-Gladin, Marica Eoli, Ruth Albarosa, Franco Carrara, Massimo Zeviani, Maria Grazia Bruzzone, Giovanni Broggi, Amerigo Boiardi, Gaetano Finocchiaro

Research output: Contribution to journalArticlepeer-review


Mutations and instability of mitochondrial DNA (mtDNA) are frequent in tumors but their pathogenic relevance is not established. To assess their role in the clinical management of malignant gliomas we have studied the D loop of mtDNA in 42 such tumors. Alterations were found in 36% of the cases. The MRI and the clinical follow-up of these patients suggest that these mutations are not associated with increased aggressiveness. mtDNA could be amplified from post-surgical tumor cavities in patients undergoing a loco-regional treatment. These results imply that mtDNA mutations are unlikely to play a role in diagnostic or prognostic evaluations of gliomas: their detection, however, could be of use for the clinical follow-up of malignant gliomas.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalJournal of Neuro-Oncology
Issue number1
Publication statusPublished - Aug 2005


  • Gliomas
  • Mitochondrial DNA
  • MRI
  • Mutations
  • Prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)


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