Inside prostate cancer news from the 2021 ASCO Genitourinary Cancers Symposium

Roberto Iacovelli, Serena Astore, Chiara Ciccarese, Maria Antonella Cannella, Pierluigi Bove, Valerio Iacovelli, Giampaolo Tortora

Research output: Contribution to journalArticlepeer-review


Background: Prostate cancer (PC) is a heterogeneous disease that requires a personalized treatment approach for proper patient management. Aim: We analyzed a selected overview of the most important news recently presented at the 2021 ASCO genitourinary cancer symposium. Results: In particular, we focused on the identification of predictive biomarkers as potential targets for therapy. Molecular signatures of increased T cell activity, proliferation, and hormone dependence were associated with greater probability of response to apalutamide in non-metastatic CRPC. Pathogenic variants of DDR genes mutations detected with circulating tumor DNA (ctDNA) analysis, which had a high concordance with tumor tissue analysis, might represent a useful way for selecting mutated patients for poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors therapy. Loss of PTEN could be a target for ipatasertib (a pan-AKT inhibitor) associated with abiraterone in mCRPC patients. Conclusions: The 2021 ASCO Genitourinary Cancers Symposium significantly contributed to the complex research goal of intimately understanding PC carcinogenesis with the ultimate aim of improving patient outcomes.

Original languageEnglish
Pages (from-to)1207-1210
Number of pages4
JournalExpert Review of Anticancer Therapy
Issue number11
Publication statusPublished - 2021


  • 2021 ASCO genitourinary cancer symposium
  • BRCA
  • immunotherapy
  • mCRPC
  • nmCRPC
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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