Insemination of HIV-negative women with processed semen of HIV-positive partners

A. E. Semprini; P. Levi-Setti; M. Bozzo; M. Ravizza; A. Taglioretti; P. Sulpizio; E. Albani; M. Oneta; G. Pardi

doi:10.1016/0140-6736(92)92495-2

Insemination of HIV-negative women with processed semen of HIV-positive partners

A. E. Semprini, P. Levi-Setti, M. Bozzo, M. Ravizza, A. Taglioretti, P. Sulpizio, E. Albani, M. Oneta, G. Pardi

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Many HIV-discordant couples want to have children so much that they are willing to abandon condom-protected sexual intercourse irrespective of the risks. Previous testing in our laboratory showed that gradient centrifugation followed by a swim-up procedure effectively removed HIV-1-infected cells from the semen of HIV-seropositive men. 85 HIV-discordant couples were screened for fertility; 29 women were found suitable for a timed insemination course with the processed semen of their HIV-seropositive partner. None of the inseminated women seroconverted, and 17 pregnancies were achieved in 15 women. All 10 babies born to these mothers remain HIV seronegative. The findings may help in the counselling of such couples and also give them hope of having healthy babies.

Original language	English
Pages (from-to)	1317-1319
Number of pages	3
Journal	Lancet
Volume	340
Issue number	8831
DOIs	https://doi.org/10.1016/0140-6736(92)92495-2
Publication status	Published - Nov 28 1992

ASJC Scopus subject areas

Medicine(all)

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10.1016/0140-6736(92)92495-2

Cite this

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abstract = "Many HIV-discordant couples want to have children so much that they are willing to abandon condom-protected sexual intercourse irrespective of the risks. Previous testing in our laboratory showed that gradient centrifugation followed by a swim-up procedure effectively removed HIV-1-infected cells from the semen of HIV-seropositive men. 85 HIV-discordant couples were screened for fertility; 29 women were found suitable for a timed insemination course with the processed semen of their HIV-seropositive partner. None of the inseminated women seroconverted, and 17 pregnancies were achieved in 15 women. All 10 babies born to these mothers remain HIV seronegative. The findings may help in the counselling of such couples and also give them hope of having healthy babies.",

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AU - Semprini, A. E.

AU - Levi-Setti, P.

AU - Bozzo, M.

AU - Ravizza, M.

AU - Taglioretti, A.

AU - Sulpizio, P.

AU - Albani, E.

AU - Oneta, M.

AU - Pardi, G.

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Insemination of HIV-negative women with processed semen of HIV-positive partners

Abstract

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