Inhibition of hepatitis B virus replication during Schistosoma mansoni infection in transgenic mice

Heike McClary, Rick Koch, Francis V. Chisari, Luca G. Guidotti

Research output: Contribution to journalArticlepeer-review


Although coinfection of hepatitis B virus (HBV) and Schistosoma mansoni is a frequent event in humans, little is known about the interactions between these two pathogens. S. mansoni infection induces T helper cell type 2 (Th2)- type cytokines in the liver of humans and mice. The intrahepatic induction of nitric oxide (NO) and Th1-type cytokines, such as interferon (IFN)-γ and IFN-α/β, inhibits HBV replication noncytopathically in the liver of transgenic mice. To examine whether S. mansoni infection and the accompanying induction of Th2-type cytokines could interfere with HBV replication in the liver, HBV transgenic mice were infected with S. mansoni. By 5 wk after infection, HBV replication disappeared concomitant with the intrahepatic induction of NO and Th1-type cytokines, and in the absence of Th2-type cytokines. By 6-8 wk after infection, HBV replication remained undetectable and this was associated with further induction of NO and Th1-type cytokines together with the appearance of Th2-type cytokines. The S. mansoni-dependent antiviral effect was partially blocked by genetically deleting IFN-γ, although it was unaffected by deletion of IFN-α/β. These results indicate that IFN-γ (probably via NO) mediates most of this antiviral activity and that Th2-type cytokines do not counteract the antiviral effect of IFN-γ. Similar events may suppress HBV replication during human S. mansoni infection.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalJournal of Experimental Medicine
Issue number2
Publication statusPublished - Jul 17 2000


  • Helminth parasites
  • Infectious immunity virus
  • Liver
  • Th1/th2 cytokines
  • Transgenic/knockout

ASJC Scopus subject areas

  • Immunology


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