TY - JOUR
T1 - Inhibition of FasL sustains phagocytic cells and delays myogenesis in regenerating muscle fibers
AU - Sandri, Marco
AU - Sandri, Claudia
AU - Brun, Barbara
AU - Giurisato, Emanuele
AU - Cantini, Marcello
AU - Rossini, Katia
AU - Destro, Chiara
AU - Arslan, Paola
AU - Carraro, Ugo
PY - 2001
Y1 - 2001
N2 - Macrophage-muscle cell interactions are complex, and the majority is unknown. The persistence of inflammatory cells in skeletal muscle could be critical for myofiber viability. In the present paper, we show that FasL plays a role in the resolution of muscle inflammation. We analyzed inflamed muscles of normal mice treated from day 3 to day 8 with a FasL inhibitor (Fas-Ig) or with control Ig. Treated muscles were collected at 3, 5, and 10 days. The treatment with recombinant Fas-Ig protein induced a severe persistence of inflammatory cells at 5 days (115,000±27,838 vs. 41,661±6848, p
AB - Macrophage-muscle cell interactions are complex, and the majority is unknown. The persistence of inflammatory cells in skeletal muscle could be critical for myofiber viability. In the present paper, we show that FasL plays a role in the resolution of muscle inflammation. We analyzed inflamed muscles of normal mice treated from day 3 to day 8 with a FasL inhibitor (Fas-Ig) or with control Ig. Treated muscles were collected at 3, 5, and 10 days. The treatment with recombinant Fas-Ig protein induced a severe persistence of inflammatory cells at 5 days (115,000±27,838 vs. 41,661±6848, p
KW - Apoptosis
KW - Differentiation
KW - Inflammation
KW - Myoblast
UR - http://www.scopus.com/inward/record.url?scp=0035100723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035100723&partnerID=8YFLogxK
M3 - Article
C2 - 11261797
AN - SCOPUS:0035100723
SN - 0741-5400
VL - 69
SP - 482
EP - 489
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 3
ER -