TY - JOUR
T1 - Inherited genetic susceptibility to monoclonal B-cell lymphocytosis
AU - Crowther-Swanepoel, Dalemari
AU - Corre, Tanguy
AU - Lloyd, Amy
AU - Gaidano, Gianluca
AU - Olver, Bianca
AU - Bennett, Fiona L.
AU - Doughty, Chi
AU - Toniolo, Daniela
AU - Calligaris-Cappio, Federico
AU - Ghia, Paolo
AU - Rossi, Davide
AU - Rawstron, Andy C.
AU - Catovsky, Daniel
AU - Houlston, Richard S.
PY - 2010/12/23
Y1 - 2010/12/23
N2 - Monoclonal B-cell lymphocytosis (MBL) is detectable in > 3% of the general population. Recent data are compatible, at least in a proportion of cases, with MBL being a progenitor lesion for chronic lymphocytic leukemia (CLL) and a surrogate for inherited predisposition. Common single nucleotide polymorphisms (SNPs) at 2q13 (rs17483466), 2q37.1 (rs13397985), 2q37.3 (rs757978), 6p25.3 (rs872071), 8q24.21 (rs2456449), 11q24.1 (rs735665), 15q21.3 (rs7169431), 15q23 (rs7176508), 16q24.1 (rs305061), and 19q13.32 (rs11083846) have been shown to confer a modest but significant increase in CLL risk. To examine the impact of these 10 SNPs on MBL, we analyzed 3 casecontrol series totaling 419 cases and 1753 controls. An association between genotype and MBL risk was seen for 9 SNPs, 6 of which were statistically significant: rs17483466 (odds ratio [OR] =1.27; P =.02), rs13397985 (OR = 1.40; P = 1.72 × 10 -3), rs757978 (OR = 1.38; P =.02), rs872071 (OR = 1.27; P = 7.75 × 10-3), rs2456449 (OR = 1.31; P = 3.14 × 10 -3), and rs735665 (OR = 1.63; P= 6.86 × 10-6). Collectively, these data provide support for genetic variation influencing CLL risk through predisposition to MBL.
AB - Monoclonal B-cell lymphocytosis (MBL) is detectable in > 3% of the general population. Recent data are compatible, at least in a proportion of cases, with MBL being a progenitor lesion for chronic lymphocytic leukemia (CLL) and a surrogate for inherited predisposition. Common single nucleotide polymorphisms (SNPs) at 2q13 (rs17483466), 2q37.1 (rs13397985), 2q37.3 (rs757978), 6p25.3 (rs872071), 8q24.21 (rs2456449), 11q24.1 (rs735665), 15q21.3 (rs7169431), 15q23 (rs7176508), 16q24.1 (rs305061), and 19q13.32 (rs11083846) have been shown to confer a modest but significant increase in CLL risk. To examine the impact of these 10 SNPs on MBL, we analyzed 3 casecontrol series totaling 419 cases and 1753 controls. An association between genotype and MBL risk was seen for 9 SNPs, 6 of which were statistically significant: rs17483466 (odds ratio [OR] =1.27; P =.02), rs13397985 (OR = 1.40; P = 1.72 × 10 -3), rs757978 (OR = 1.38; P =.02), rs872071 (OR = 1.27; P = 7.75 × 10-3), rs2456449 (OR = 1.31; P = 3.14 × 10 -3), and rs735665 (OR = 1.63; P= 6.86 × 10-6). Collectively, these data provide support for genetic variation influencing CLL risk through predisposition to MBL.
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U2 - 10.1182/blood-2010-07-294975
DO - 10.1182/blood-2010-07-294975
M3 - Article
C2 - 20855867
AN - SCOPUS:78650646957
SN - 0006-4971
VL - 116
SP - 5957
EP - 5960
JO - Blood
JF - Blood
IS - 26
ER -