Infliximab therapy in pediatric Takayasu's arteritis: Report of two cases

Paola Sabrina Buonuomo; Claudia Bracaglia; Andrea Campana; Antonella Insalaco; Manuela Pardeo; Elisabetta Cortis; Alberto G. Ugazio

doi:10.1007/s00296-009-1147-5

Infliximab therapy in pediatric Takayasu's arteritis: Report of two cases

Paola Sabrina Buonuomo, Claudia Bracaglia, Andrea Campana, Antonella Insalaco, Manuela Pardeo, Elisabetta Cortis, Alberto G. Ugazio

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology. Experience with anti-tumor necrosis factor alpha (anti-TNF) agents in difficult-to-treat patients with TA is limited and refers to adult patients. Here, we present two cases of pediatric TA treated with infliximab, in which clinical remission was observed. Anti-TNF treatment represents a useful therapy in pediatric Takayasu arteritis too, especially to avoid the risk of long-term corticosteroids toxicity.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Rheumatology International
Volume	31
Issue number	1
DOIs	https://doi.org/10.1007/s00296-009-1147-5
Publication status	Published - Jan 2011

Keywords

Arteritis
Biologic agents
Pediatric
Vasculitis

ASJC Scopus subject areas

Rheumatology
Immunology
Immunology and Allergy

Access to Document

10.1007/s00296-009-1147-5

Cite this

@article{054641392c05474e8736c0c62085944a,

title = "Infliximab therapy in pediatric Takayasu's arteritis: Report of two cases",

abstract = "Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology. Experience with anti-tumor necrosis factor alpha (anti-TNF) agents in difficult-to-treat patients with TA is limited and refers to adult patients. Here, we present two cases of pediatric TA treated with infliximab, in which clinical remission was observed. Anti-TNF treatment represents a useful therapy in pediatric Takayasu arteritis too, especially to avoid the risk of long-term corticosteroids toxicity.",

keywords = "Arteritis, Biologic agents, Pediatric, Vasculitis",

author = "Buonuomo, {Paola Sabrina} and Claudia Bracaglia and Andrea Campana and Antonella Insalaco and Manuela Pardeo and Elisabetta Cortis and Ugazio, {Alberto G.}",

year = "2011",

month = jan,

doi = "10.1007/s00296-009-1147-5",

language = "English",

volume = "31",

pages = "93--95",

journal = "Rheumatology International",

issn = "0172-8172",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Infliximab therapy in pediatric Takayasu's arteritis

T2 - Report of two cases

AU - Buonuomo, Paola Sabrina

AU - Bracaglia, Claudia

AU - Campana, Andrea

AU - Insalaco, Antonella

AU - Pardeo, Manuela

AU - Cortis, Elisabetta

AU - Ugazio, Alberto G.

PY - 2011/1

Y1 - 2011/1

N2 - Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology. Experience with anti-tumor necrosis factor alpha (anti-TNF) agents in difficult-to-treat patients with TA is limited and refers to adult patients. Here, we present two cases of pediatric TA treated with infliximab, in which clinical remission was observed. Anti-TNF treatment represents a useful therapy in pediatric Takayasu arteritis too, especially to avoid the risk of long-term corticosteroids toxicity.

AB - Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology. Experience with anti-tumor necrosis factor alpha (anti-TNF) agents in difficult-to-treat patients with TA is limited and refers to adult patients. Here, we present two cases of pediatric TA treated with infliximab, in which clinical remission was observed. Anti-TNF treatment represents a useful therapy in pediatric Takayasu arteritis too, especially to avoid the risk of long-term corticosteroids toxicity.

KW - Arteritis

KW - Biologic agents

KW - Pediatric

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=78751585470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751585470&partnerID=8YFLogxK

U2 - 10.1007/s00296-009-1147-5

DO - 10.1007/s00296-009-1147-5

M3 - Article

C2 - 19851773

AN - SCOPUS:78751585470

SN - 0172-8172

VL - 31

SP - 93

EP - 95

JO - Rheumatology International

JF - Rheumatology International

IS - 1

ER -

Infliximab therapy in pediatric Takayasu's arteritis: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this