Inefficacy of immediate node dissection in stage 1 melanoma of the limbs

U. Veronesi; J. Adamus; C. Bandiera; I. O. Brennhovd; E. Caceres; N. Cascinelli; F. Claudio; R. L. Ikonopisov; V. V. Javorskj; S. Kirov; A. Kulakowski; J. Lacoub; F. Lejeune; Z. Mechl; A. Morabito; I. Rodé; S. Sergeev; E. van Slooten; K. Szcygiel; N. N. Trapeznikov

Inefficacy of immediate node dissection in stage 1 melanoma of the limbs

U. Veronesi, J. Adamus, C. Bandiera, I. O. Brennhovd, E. Caceres, N. Cascinelli, F. Claudio, R. L. Ikonopisov, V. V. Javorskj, S. Kirov, A. Kulakowski, J. Lacoub, F. Lejeune, Z. Mechl, A. Morabito, I. Rodé, S. Sergeev, E. van Slooten, K. Szcygiel, N. N. Trapeznikov

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

From 1967 to 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the 2 groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness). Elective lymph-node dissection in malignant melanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of 3 mth.

Original language	English
Pages (from-to)	627-630
Number of pages	4
Journal	New England Journal of Medicine
Volume	297
Issue number	12
Publication status	Published - 1977

ASJC Scopus subject areas

Medicine(all)

Cite this

Veronesi, U., Adamus, J., Bandiera, C., Brennhovd, I. O., Caceres, E., Cascinelli, N., Claudio, F., Ikonopisov, R. L., Javorskj, V. V., Kirov, S., Kulakowski, A., Lacoub, J., Lejeune, F., Mechl, Z., Morabito, A., Rodé, I., Sergeev, S., van Slooten, E., Szcygiel, K., & Trapeznikov, N. N. (1977). Inefficacy of immediate node dissection in stage 1 melanoma of the limbs. New England Journal of Medicine, 297(12), 627-630.

Veronesi, U, Adamus, J, Bandiera, C, Brennhovd, IO, Caceres, E, Cascinelli, N, Claudio, F, Ikonopisov, RL, Javorskj, VV, Kirov, S, Kulakowski, A, Lacoub, J, Lejeune, F, Mechl, Z, Morabito, A, Rodé, I, Sergeev, S, van Slooten, E, Szcygiel, K & Trapeznikov, NN 1977, 'Inefficacy of immediate node dissection in stage 1 melanoma of the limbs', New England Journal of Medicine, vol. 297, no. 12, pp. 627-630.

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title = "Inefficacy of immediate node dissection in stage 1 melanoma of the limbs",

abstract = "From 1967 to 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the 2 groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness). Elective lymph-node dissection in malignant melanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of 3 mth.",

author = "U. Veronesi and J. Adamus and C. Bandiera and Brennhovd, {I. O.} and E. Caceres and N. Cascinelli and F. Claudio and Ikonopisov, {R. L.} and Javorskj, {V. V.} and S. Kirov and A. Kulakowski and J. Lacoub and F. Lejeune and Z. Mechl and A. Morabito and I. Rod{\'e} and S. Sergeev and {van Slooten}, E. and K. Szcygiel and Trapeznikov, {N. N.}",

year = "1977",

language = "English",

volume = "297",

pages = "627--630",

journal = "New England Journal of Medicine",

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T1 - Inefficacy of immediate node dissection in stage 1 melanoma of the limbs

AU - Veronesi, U.

AU - Adamus, J.

AU - Bandiera, C.

AU - Brennhovd, I. O.

AU - Caceres, E.

AU - Cascinelli, N.

AU - Claudio, F.

AU - Ikonopisov, R. L.

AU - Javorskj, V. V.

AU - Kirov, S.

AU - Kulakowski, A.

AU - Lacoub, J.

AU - Lejeune, F.

AU - Mechl, Z.

AU - Morabito, A.

AU - Rodé, I.

AU - Sergeev, S.

AU - van Slooten, E.

AU - Szcygiel, K.

AU - Trapeznikov, N. N.

PY - 1977

Y1 - 1977

N2 - From 1967 to 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the 2 groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness). Elective lymph-node dissection in malignant melanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of 3 mth.

AB - From 1967 to 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the 2 groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness). Elective lymph-node dissection in malignant melanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of 3 mth.

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C2 - 895764

AN - SCOPUS:0017698676

SN - 0028-4793

VL - 297

SP - 627

EP - 630

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 12

ER -

Inefficacy of immediate node dissection in stage 1 melanoma of the limbs

Abstract

ASJC Scopus subject areas

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