Increased oxidative-related mechanisms in the spinal cord injury in old rats

Tiziana Genovese, Emanuela Mazzon, Rosanna Di Paola, Concetta Crisafulli, Carmelo Muià, Placido Bramanti, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review


In the present study, we evaluated the effect of age, in a model of spinal cord injury that was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in old rats resulted in severe trauma characterized by edema and neutrophil infiltration. Immunohistochemical examination demonstrated an increase in immunoreactivity for nitrotyrosine. In contrast, the degree of: (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) PARS, and (d) neutrophils infiltration was markedly reduced in spinal cord tissue obtained from young rats. We have also demonstrated that ageing significantly worsened the recovery of limb function and caused an increase in mortality rate when compared with young rats.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - Jan 30 2006


  • Free radicals
  • Oxidative stress
  • Secondary injury
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)


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