Increased oxidative-related mechanisms in the spinal cord injury in old rats

Tiziana Genovese; Emanuela Mazzon; Rosanna Di Paola; Concetta Crisafulli; Carmelo Muià; Placido Bramanti; Salvatore Cuzzocrea

doi:10.1016/j.neulet.2005.09.060

Increased oxidative-related mechanisms in the spinal cord injury in old rats

Tiziana Genovese, Emanuela Mazzon, Rosanna Di Paola, Concetta Crisafulli, Carmelo Muià, Placido Bramanti, Salvatore Cuzzocrea

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study, we evaluated the effect of age, in a model of spinal cord injury that was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in old rats resulted in severe trauma characterized by edema and neutrophil infiltration. Immunohistochemical examination demonstrated an increase in immunoreactivity for nitrotyrosine. In contrast, the degree of: (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) PARS, and (d) neutrophils infiltration was markedly reduced in spinal cord tissue obtained from young rats. We have also demonstrated that ageing significantly worsened the recovery of limb function and caused an increase in mortality rate when compared with young rats.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	Neuroscience Letters
Volume	393
Issue number	2-3
DOIs	https://doi.org/10.1016/j.neulet.2005.09.060
Publication status	Published - Jan 30 2006

Keywords

Free radicals
Oxidative stress
Secondary injury
Spinal cord injury

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2005.09.060

Cite this

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abstract = "In the present study, we evaluated the effect of age, in a model of spinal cord injury that was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in old rats resulted in severe trauma characterized by edema and neutrophil infiltration. Immunohistochemical examination demonstrated an increase in immunoreactivity for nitrotyrosine. In contrast, the degree of: (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) PARS, and (d) neutrophils infiltration was markedly reduced in spinal cord tissue obtained from young rats. We have also demonstrated that ageing significantly worsened the recovery of limb function and caused an increase in mortality rate when compared with young rats.",

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AU - Genovese, Tiziana

AU - Mazzon, Emanuela

AU - Di Paola, Rosanna

AU - Crisafulli, Concetta

AU - Muià, Carmelo

AU - Bramanti, Placido

AU - Cuzzocrea, Salvatore

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KW - Free radicals

KW - Oxidative stress

KW - Secondary injury

KW - Spinal cord injury

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Increased oxidative-related mechanisms in the spinal cord injury in old rats

Abstract

Keywords

ASJC Scopus subject areas

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