Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

M. Faronato; G. Muzzonigro; G. Milanese; C. Menna; A. R. Bonfigli; A. Catalano; A. Procopio

Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

M. Faronato, G. Muzzonigro, G. Milanese, C. Menna, A. R. Bonfigli, A. Catalano, A. Procopio

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CC-RCC development, we examined whether the 5-Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P

Original language	English
Pages (from-to)	1109-1118
Number of pages	10
Journal	Histology and Histopathology
Volume	22
Issue number	10-12
Publication status	Published - Oct 2007

Keywords

5-lipoxygenase
Eiocasanoids
Renal cell carcinoma
Tumor progression

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine
Histology
Cell Biology

Cite this

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abstract = "The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CC-RCC development, we examined whether the 5-Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P",

keywords = "5-lipoxygenase, Eiocasanoids, Renal cell carcinoma, Tumor progression",

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T1 - Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

AU - Faronato, M.

AU - Muzzonigro, G.

AU - Milanese, G.

AU - Menna, C.

AU - Bonfigli, A. R.

AU - Catalano, A.

AU - Procopio, A.

PY - 2007/10

Y1 - 2007/10

N2 - The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CC-RCC development, we examined whether the 5-Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P

AB - The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CC-RCC development, we examined whether the 5-Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P

KW - 5-lipoxygenase

KW - Eiocasanoids

KW - Renal cell carcinoma

KW - Tumor progression

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SN - 0213-3911

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EP - 1118

JO - Histology and Histopathology

JF - Histology and Histopathology

IS - 10-12

ER -

Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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