Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

M. Faronato, G. Muzzonigro, G. Milanese, C. Menna, A. R. Bonfigli, A. Catalano, A. Procopio

Research output: Contribution to journalArticlepeer-review


The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CC-RCC development, we examined whether the 5-Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P

Original languageEnglish
Pages (from-to)1109-1118
Number of pages10
JournalHistology and Histopathology
Issue number10-12
Publication statusPublished - Oct 2007


  • 5-lipoxygenase
  • Eiocasanoids
  • Renal cell carcinoma
  • Tumor progression

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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