Increased activation effects of succinylcholine in neurosurgical patients

F. Fiacchino, C. Giorgi, C. Ferrazza, M. Montolivo, M. Bricchi, L. Ferrario, F. Pluchino, V. Borroni

Research output: Contribution to journalArticlepeer-review


Succinylcholine, a depolarizing muscle relaxant with both activating and desensitizing effects, is used to facilitate endotracheal intubation. The activating effects were found to be above-normal on induction of anesthesia in 7 neurosurgical patients: generalized muscle spasm in 1 myotonic patient, contractures or prolonged contractions in "anatomically" denervated muscles (1 patient), in "functionally" denervated muscles (1 patient) and in "centrally" denervated muscles (4 patients). One of these four presented hyperkalemia and cardiocirculatory collapse. It is important to differentiate these anomalous responses to succinylcholine from those occurring as early signs of rhabdomyolysis or malignant hyperthermia.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalItalian Journal of Neurological Sciences
Issue number1
Publication statusPublished - Apr 1983


  • decentralization
  • denervation
  • succinylcholine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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