Incidence of second primary cancer in transplanted patients

Emanuela Taioli, Pierluca Piselli, Eloisa Arbustini, Luigi Boschiero, Patrizia Burra, Ghil Busnach, Rossana Caldara, Franco Citterio, Emanuela De Juli, Daniela Dissegna, Eliana Gotti, Francesco Marchini, Maria Cristina Maresca, Luigina Marsano, Giuseppe Montagnino, Domenico Montanaro, Silvio Sandrini, Paola Pedotti, Mario Scalamogna, Diego Serraino

Research output: Contribution to journalArticlepeer-review


Background. Solid organ transplanted patients have a three- to fourfold higher lifetime risk of developing a cancer than the general population. However, the incidence of a second primary cancer in transplanted patients has never been studied, despite the fact that the presence of regular follow-ups and the increased survival of these patients make them a very attractive model. Methods. We investigated the incidence of a second primary cancer (SPC) in 7,636 patients who underwent a kidney, liver, lung or heart transplant between 1970 and 2004, and were followed-up for 51,819 person-years. Results. During the follow-up, 499 subjects developed a first cancer (annual incidence: 98.6X10,000 PY), and 22 of them developed a SPC (annual incidence: 3.9X10,000 PY). The annual incidence of a SPC in the transplanted patients who developed a first cancer was 107.8X10,000 PY, giving a standardized incidence ratio of 1.1 (95% CI: 0.83-1.41). Conclusions. This result shows that the incidence of the SPC was the same as the incidence of a first cancer. Our study does not indicate an increased risk of SPC in transplanted subjects who already suffered a first malignancy.

Original languageEnglish
Pages (from-to)982-985
Number of pages4
Issue number7
Publication statusPublished - Apr 2006


  • Cohort study
  • Epidemiology
  • Solid organ transplant

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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