Incidence and prognosis of brain abscess in a defined population: Olmsted county, Minnesota, 1935-1981

Alfredo Nicoiosi; W. Allen Hauser; Massimo Musicco; Leonard T. Kurland

doi:10.1159/000110257

Incidence and prognosis of brain abscess in a defined population: Olmsted county, Minnesota, 1935-1981

Alfredo Nicoiosi, W. Allen Hauser, Massimo Musicco, Leonard T. Kurland

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100, 000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935-44 to 0.9 in 1965-81. Rates were higher in children 5-9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.

Original language	English
Pages (from-to)	122-131
Number of pages	10
Journal	Neuroepidemiology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1159/000110257
Publication status	Published - 1991

Keywords

Brain abscess
Central nervous system infection
Epidemiology
Incidence
Mortality

ASJC Scopus subject areas

Epidemiology
Clinical Neurology

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10.1159/000110257

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title = "Incidence and prognosis of brain abscess in a defined population: Olmsted county, Minnesota, 1935-1981",

abstract = "The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100, 000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935-44 to 0.9 in 1965-81. Rates were higher in children 5-9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.",

keywords = "Brain abscess, Central nervous system infection, Epidemiology, Incidence, Mortality",

author = "Alfredo Nicoiosi and Hauser, {W. Allen} and Massimo Musicco and Kurland, {Leonard T.}",

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doi = "10.1159/000110257",

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AU - Nicoiosi, Alfredo

AU - Hauser, W. Allen

AU - Musicco, Massimo

AU - Kurland, Leonard T.

PY - 1991

Y1 - 1991

N2 - The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100, 000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935-44 to 0.9 in 1965-81. Rates were higher in children 5-9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.

AB - The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100, 000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935-44 to 0.9 in 1965-81. Rates were higher in children 5-9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.

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KW - Central nervous system infection

KW - Epidemiology

KW - Incidence

KW - Mortality

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Incidence and prognosis of brain abscess in a defined population: Olmsted county, Minnesota, 1935-1981

Abstract

Keywords

ASJC Scopus subject areas

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