Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect

Wan Yun Ma; Ida Ortalli; Giuseppe Pedrazzi; Silvia Vaccari; Carmelo Carlo-Stella

Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect

Wan Yun Ma, Ida Ortalli, Giuseppe Pedrazzi, Silvia Vaccari, Carmelo Carlo-Stella

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a ⁵⁷Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.

Original language	English
Pages (from-to)	419-423
Number of pages	5
Journal	Anticancer Research
Volume	18
Issue number	1 A
Publication status	Published - Jan 1998

Keywords

Bone marrow
Inactivation
K652
Mossbauer effect

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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abstract = "Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.",

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T1 - Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect

AU - Ma, Wan Yun

AU - Ortalli, Ida

AU - Pedrazzi, Giuseppe

AU - Vaccari, Silvia

AU - Carlo-Stella, Carmelo

PY - 1998/1

Y1 - 1998/1

N2 - Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.

AB - Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.

KW - Bone marrow

KW - Inactivation

KW - K652

KW - Mossbauer effect

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JO - Anticancer Research

JF - Anticancer Research

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ER -

Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect

Abstract

Keywords

ASJC Scopus subject areas

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