TY - JOUR
T1 - In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli
AU - Spanu, Teresa
AU - De Angelis, Giulia
AU - Cipriani, Michela
AU - Pedruzzi, Barbara
AU - D'Inzeo, Tiziana
AU - Cataldo, Maria Adriana
AU - Sganga, Gabriele
AU - Tacconelli, Evelina
PY - 2012/8
Y1 - 2012/8
N2 - Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3)-producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.
AB - Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3)-producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.
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U2 - 10.1128/AAC.00234-12
DO - 10.1128/AAC.00234-12
M3 - Article
C2 - 22644031
AN - SCOPUS:84864379255
SN - 0066-4804
VL - 56
SP - 4516
EP - 4518
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -