In vivo effects of maternal immunosupression during pregnancy on the immune function of newborn infants

Elisa Meregalli; Martina Biggioggero; Orietta Borghi; Pierluigi Meroni; Rolando Cimaz

In vivo effects of maternal immunosupression during pregnancy on the immune function of newborn infants

Elisa Meregalli, Martina Biggioggero, Orietta Borghi, Pierluigi Meroni, Rolando Cimaz

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

When used in pregnancy, immunosuppressants can cross the placental barrier and enter foetal circulation, possibly affecting the immune system of the foetus. This study evaluated the immune function in eight children born by mothers with connective tissue diseases who received immunosuppressants (cyclosporine A or dexamethasone) during pregnancy and in six babies from mothers with similar diseases, but who did not receive any treatment. Judging by the cytokine production of interleukin-2 and interferon-γ in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	Arhiv za Higijenu Rada i Toksikologiju
Volume	56
Issue number	2
Publication status	Published - Jun 2005

Keywords

Cyclosporine A
Dexamethasone
Immune function
Immunosuppressants
Newborns
Vaccination

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Toxicology

Cite this

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AU - Meroni, Pierluigi

AU - Cimaz, Rolando

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AB - When used in pregnancy, immunosuppressants can cross the placental barrier and enter foetal circulation, possibly affecting the immune system of the foetus. This study evaluated the immune function in eight children born by mothers with connective tissue diseases who received immunosuppressants (cyclosporine A or dexamethasone) during pregnancy and in six babies from mothers with similar diseases, but who did not receive any treatment. Judging by the cytokine production of interleukin-2 and interferon-γ in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.

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KW - Vaccination

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In vivo effects of maternal immunosupression during pregnancy on the immune function of newborn infants

Abstract

Keywords

ASJC Scopus subject areas

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