In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

V. Di Lazzaro; F. Pilato; M. Dileone; E. Saturno; A. Oliviero; C. Marra; A. Daniele; F. Ranieri; G. Gainotti; P. A. Tonali

doi:10.1212/01.wnl.0000204183.26231.23

In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

V. Di Lazzaro, F. Pilato, M. Dileone, E. Saturno, A. Oliviero, C. Marra, A. Daniele, F. Ranieri, G. Gainotti, P. A. Tonali

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.

Original language	English
Pages (from-to)	1111-1113
Number of pages	3
Journal	Neurology
Volume	66
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000204183.26231.23
Publication status	Published - Apr 2006

ASJC Scopus subject areas

Neuroscience(all)

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AU - Di Lazzaro, V.

AU - Pilato, F.

AU - Dileone, M.

AU - Saturno, E.

AU - Oliviero, A.

AU - Marra, C.

AU - Daniele, A.

AU - Ranieri, F.

AU - Gainotti, G.

AU - Tonali, P. A.

PY - 2006/4

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AB - The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.

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In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

Abstract

ASJC Scopus subject areas

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