In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine

Daniela Pende; Francesco Indiveri; Ivana Pierri; Domenico Criscuolo; Soldano Ferrone

doi:10.1016/0162-3109(86)90020-2

In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine

Daniela Pende, Francesco Indiveri, Ivana Pierri, Domenico Criscuolo, Soldano Ferrone

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

While high doses of hydralazine inhibit the proliferative response of T lymphocytes to mitogens and antigens, low doses (0.15 μg/ml) selectively enhance the proliferative respone of T cells to autologous non-T cells. The effect is especially pronounced on lymphocytes which express the HLA-DR4 allospecificity. These results suggest that the autologous mixed lymphocyte response with non-T-cells may represent a useful in vitro model to analyse the mechanism(s) of the immunologic abnormalities induced by hydrazaline.

Original language	English
Pages (from-to)	183-187
Number of pages	5
Journal	Immunopharmacology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(86)90020-2
Publication status	Published - 1986

Keywords

Autologous mixed lymphocyte reactions
HLA Class II antigens
Hydralazine
T cells

ASJC Scopus subject areas

Pharmacology

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10.1016/0162-3109(86)90020-2

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title = "In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine",

abstract = "While high doses of hydralazine inhibit the proliferative response of T lymphocytes to mitogens and antigens, low doses (0.15 μg/ml) selectively enhance the proliferative respone of T cells to autologous non-T cells. The effect is especially pronounced on lymphocytes which express the HLA-DR4 allospecificity. These results suggest that the autologous mixed lymphocyte response with non-T-cells may represent a useful in vitro model to analyse the mechanism(s) of the immunologic abnormalities induced by hydrazaline.",

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T1 - In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine

AU - Pende, Daniela

AU - Indiveri, Francesco

AU - Pierri, Ivana

AU - Criscuolo, Domenico

AU - Ferrone, Soldano

PY - 1986

Y1 - 1986

N2 - While high doses of hydralazine inhibit the proliferative response of T lymphocytes to mitogens and antigens, low doses (0.15 μg/ml) selectively enhance the proliferative respone of T cells to autologous non-T cells. The effect is especially pronounced on lymphocytes which express the HLA-DR4 allospecificity. These results suggest that the autologous mixed lymphocyte response with non-T-cells may represent a useful in vitro model to analyse the mechanism(s) of the immunologic abnormalities induced by hydrazaline.

AB - While high doses of hydralazine inhibit the proliferative response of T lymphocytes to mitogens and antigens, low doses (0.15 μg/ml) selectively enhance the proliferative respone of T cells to autologous non-T cells. The effect is especially pronounced on lymphocytes which express the HLA-DR4 allospecificity. These results suggest that the autologous mixed lymphocyte response with non-T-cells may represent a useful in vitro model to analyse the mechanism(s) of the immunologic abnormalities induced by hydrazaline.

KW - Autologous mixed lymphocyte reactions

KW - HLA Class II antigens

KW - Hydralazine

KW - T cells

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In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine

Abstract

Keywords

ASJC Scopus subject areas

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