In vitro effects of cyclosporine A on allogeneic and autologous lymphocyte stimulation: Influence of HLA phenotypes

R. Scorza; M. Vanoli; A. Cigognini; G. Fabio; B. De Bernardi; C. Zanussi

In vitro effects of cyclosporine A on allogeneic and autologous lymphocyte stimulation: Influence of HLA phenotypes

R. Scorza, M. Vanoli, A. Cigognini, G. Fabio, B. De Bernardi, C. Zanussi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.

Original language	English
Pages (from-to)	122-124
Number of pages	3
Journal	Transplantation Proceedings
Volume	20
Issue number	2 SUPPL. 2
Publication status	Published - 1988

ASJC Scopus subject areas

Surgery
Transplantation

Cite this

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abstract = "Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.",

author = "R. Scorza and M. Vanoli and A. Cigognini and G. Fabio and {De Bernardi}, B. and C. Zanussi",

year = "1988",

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T2 - Influence of HLA phenotypes

AU - Scorza, R.

AU - Vanoli, M.

AU - Cigognini, A.

AU - Fabio, G.

AU - De Bernardi, B.

AU - Zanussi, C.

PY - 1988

Y1 - 1988

N2 - Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.

AB - Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.

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IS - 2 SUPPL. 2

ER -

In vitro effects of cyclosporine A on allogeneic and autologous lymphocyte stimulation: Influence of HLA phenotypes

Abstract

ASJC Scopus subject areas

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