Abstract
Objective: Evaluation of the cytolytic effect of intragastric bile acids collected from postoperative patients with different degrees of duodenogastric reflux. Patients and Methods: The study included 60 patients, 26 of whom had undergone cholecystectomy for gallstones (group A), while the other 34 had undergone a Billroth II gastric resection for peptic ulcer disease (group B). Intragastric bile acid concentration was evaluated after a 12-h fast by drainage of gastric contents every 15 min for 1 h using a nasogastric tube. The total bile acid (TBA) concentrations were measured by an enzymatic method. Cytotoxicity of gastric juice was assessed by haemolysis of human erythrocytes and expressed as ü of gastric juice required for 50% haemolysis (C50). Results: Group B patients had higher intragastric TBA levels than those from group A (P<0.05). This was paralleled by the significantly greater in vitro cytolytic activity exhibited by gastric juice from group B compared with group A patients (P
| Original language | English |
|---|---|
| Pages (from-to) | 603-606 |
| Number of pages | 4 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 6 |
| Issue number | 7 |
| Publication status | Published - 1994 |
Keywords
- Bile acids
- Cytolytic activity
- Duodenogastric reflux
ASJC Scopus subject areas
- Gastroenterology
- Hepatology