In vitro biocompatibility of a polyurethane catheter after deposition of fluorinated film

A. Pizzoferrato; C. R. Arciola; E. Cenni; G. Ciapetti; S. Sassi

doi:10.1016/0142-9612(95)93853-6

In vitro biocompatibility of a polyurethane catheter after deposition of fluorinated film

A. Pizzoferrato, C. R. Arciola, E. Cenni, G. Ciapetti, S. Sassi

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro biocompatibility of an experimental surface-treated polyurethane was compared with an untreated polyurethane already used for intravascular catheters. The experimental surface was coated with a fluorinated film using a glow discharge treatment. Neither of the catheters was cytotoxic for L929 murine fibroblasts, caused platelet adhesion or release reaction, or changed the mean platelet volume. The surface-treated polyurethane, however, caused a higher adhesion of Staphylococcus aureus than did the untreated one. Therefore, using in vitro testing, it has been ascertained that the examined material, though not being cytotoxic and not modifying platelet behaviour, could favour bacterial adherence.

Original language	English
Pages (from-to)	361-367
Number of pages	7
Journal	Biomaterials
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/0142-9612(95)93853-6
Publication status	Published - 1995

Keywords

cytotoxicity
haemocompatibility
infection
Polyurethanes

ASJC Scopus subject areas

Biophysics
Bioengineering
Mechanics of Materials
Biomaterials
Ceramics and Composites
Biotechnology
Biomedical Engineering

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10.1016/0142-9612(95)93853-6

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abstract = "The in vitro biocompatibility of an experimental surface-treated polyurethane was compared with an untreated polyurethane already used for intravascular catheters. The experimental surface was coated with a fluorinated film using a glow discharge treatment. Neither of the catheters was cytotoxic for L929 murine fibroblasts, caused platelet adhesion or release reaction, or changed the mean platelet volume. The surface-treated polyurethane, however, caused a higher adhesion of Staphylococcus aureus than did the untreated one. Therefore, using in vitro testing, it has been ascertained that the examined material, though not being cytotoxic and not modifying platelet behaviour, could favour bacterial adherence.",

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AU - Pizzoferrato, A.

AU - Arciola, C. R.

AU - Cenni, E.

AU - Ciapetti, G.

AU - Sassi, S.

PY - 1995

Y1 - 1995

N2 - The in vitro biocompatibility of an experimental surface-treated polyurethane was compared with an untreated polyurethane already used for intravascular catheters. The experimental surface was coated with a fluorinated film using a glow discharge treatment. Neither of the catheters was cytotoxic for L929 murine fibroblasts, caused platelet adhesion or release reaction, or changed the mean platelet volume. The surface-treated polyurethane, however, caused a higher adhesion of Staphylococcus aureus than did the untreated one. Therefore, using in vitro testing, it has been ascertained that the examined material, though not being cytotoxic and not modifying platelet behaviour, could favour bacterial adherence.

AB - The in vitro biocompatibility of an experimental surface-treated polyurethane was compared with an untreated polyurethane already used for intravascular catheters. The experimental surface was coated with a fluorinated film using a glow discharge treatment. Neither of the catheters was cytotoxic for L929 murine fibroblasts, caused platelet adhesion or release reaction, or changed the mean platelet volume. The surface-treated polyurethane, however, caused a higher adhesion of Staphylococcus aureus than did the untreated one. Therefore, using in vitro testing, it has been ascertained that the examined material, though not being cytotoxic and not modifying platelet behaviour, could favour bacterial adherence.

KW - cytotoxicity

KW - haemocompatibility

KW - infection

KW - Polyurethanes

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In vitro biocompatibility of a polyurethane catheter after deposition of fluorinated film

Abstract

Keywords

ASJC Scopus subject areas

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