In-hospital mortality and failure to rescue after cytoreductive nephrectomy

Quoc Dien Trinh, Marco Bianchi, Jens Hansen, Zhe Tian, Firas Abdollah, Shahrokh F. Shariat, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz, Maxine Sun

Research output: Contribution to journalArticlepeer-review


Background: The risk of in-hospital mortality after cytoreductive nephrectomy (CNT) is non-negligible and may vary widely according to various patient and hospital characteristics and clinical contexts. Objective: To better elucidate the mechanisms underlying variability in operative mortality after CNT. Design, setting, and patients: Using the US-based Nationwide Inpatient Sample registry, a weighted estimate of 16 285 patients with metastatic renal cell carcinoma (mRCC) treated with CNT between 1998 and 2007 was made retrospectively. Outcome measurements and statistical analysis: Failure to rescue (FTR), defined as the number of deaths in patients who developed an adverse outcome during hospitalization. Univariable and multivariable logistic regression models were used. Results: Of all 16 285 mRCC patients who underwent a CNT, 31% had an occurrence of one complication or more. The overall FTR rate was 5% and differed significantly according to age (≥75 yr vs

Original languageEnglish
Pages (from-to)1107-1114
Number of pages8
JournalEuropean Urology
Issue number6
Publication statusPublished - Jun 2013


  • Cytoreductive nephrectomy
  • In-hospital mortality
  • Metastatic renal cell carcinoma
  • Morbidity

ASJC Scopus subject areas

  • Urology


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