Improvement of CXCR3 ligand CXCL11/I-TAC measurement in human plasma and serum

Viviana Cremasco, Barbara Mantelli, Adriano Lazzarin, Priscilla Biswas

Research output: Contribution to journalArticlepeer-review


The chemokine receptor CXCR3 is involved in cell trafficking dysregulation associated with several inflammatory conditions, including autoimmune and viral diseases. Downregulation of CXCR3, through binding with its ligand CXCL111(I-TAC), represents a key mechanism in lymphocyte recruitment. Determination of circulating I-TAC can provide useful information in the investigation of inflammatory/infectious conditions. The existing commercial kit does not measure CXCL11/I-TAC in complex matrices, such as human plasma and serum, as reliably as in in vitro-generated cell culture supernatants. We here describe means which lead to an improvement of CXCL11/I-TAC measurement in human plasma and serum.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalNew Microbiologica
Issue number1
Publication statusPublished - Jan 2009


  • Cell trafficking
  • Chemokine receptors
  • Chemokines
  • CXCL11/I-TAC
  • CXCR3

ASJC Scopus subject areas

  • Microbiology (medical)


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