Improvement in outcomes of clinical islet transplantation: 1999-2010

Franca B. Barton; Michael R. Rickels; Rodolfo Alejandro; Bernhard J. Hering; Stephen Wease; Bashoo Naziruddin; Jose Oberholzer; Jon S. Odorico; Marc R. Garfinkel; Marlon Levy; Francois Pattou; Thierry Berney; Antonio Secchi; Shari Messinger; Peter A. Senior; Paola Maffi; Andrew Posselt; Peter G. Stock; Dixon B. Kaufman; Xunrong Luo; Fouad Kandeel; Enrico Cagliero; Nicole A. Turgeon; Piotr Witkowski; Ali Naji; Philip J. O'Connell; Carla Greenbaum; Yogish C. Kudva; Kenneth L. Brayman; Meredith J. Aull; Christian Larsen; Tom W H Kay; Luis A. Fernandez; Marie Christine Vantyghem; Melena Bellin; A. M James Shapiro

doi:10.2337/dc12-0063

Improvement in outcomes of clinical islet transplantation: 1999-2010

Franca B. Barton, Michael R. Rickels, Rodolfo Alejandro, Bernhard J. Hering, Stephen Wease, Bashoo Naziruddin, Jose Oberholzer, Jon S. Odorico, Marc R. Garfinkel, Marlon Levy, Francois Pattou, Thierry Berney, Antonio Secchi, Shari Messinger, Peter A. Senior, Paola Maffi, Andrew Posselt, Peter G. Stock, Dixon B. Kaufman, Xunrong LuoFouad Kandeel, Enrico Cagliero, Nicole A. Turgeon, Piotr Witkowski, Ali Naji, Philip J. O'Connell, Carla Greenbaum, Yogish C. Kudva, Kenneth L. Brayman, Meredith J. Aull, Christian Larsen, Tom W H Kay, Luis A. Fernandez, Marie Christine Vantyghem, Melena Bellin, A. M James Shapiro

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE - To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS - A total of 677 islet transplant-alone or isletafter- kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS - Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function,was retained longer in themost recent era (P

Original language	English
Pages (from-to)	1436-1445
Number of pages	10
Journal	Diabetes Care
Volume	35
Issue number	7
DOIs	https://doi.org/10.2337/dc12-0063
Publication status	Published - Jul 2012

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialised Nursing

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10.2337/dc12-0063

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Barton, F. B., Rickels, M. R., Alejandro, R., Hering, B. J., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J. S., Garfinkel, M. R., Levy, M., Pattou, F., Berney, T., Secchi, A., Messinger, S., Senior, P. A., Maffi, P., Posselt, A., Stock, P. G., Kaufman, D. B., ... Shapiro, A. M. J. (2012). Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care, 35(7), 1436-1445. https://doi.org/10.2337/dc12-0063

Barton, FB, Rickels, MR, Alejandro, R, Hering, BJ, Wease, S, Naziruddin, B, Oberholzer, J, Odorico, JS, Garfinkel, MR, Levy, M, Pattou, F, Berney, T, Secchi, A, Messinger, S, Senior, PA, Maffi, P, Posselt, A, Stock, PG, Kaufman, DB, Luo, X, Kandeel, F, Cagliero, E, Turgeon, NA, Witkowski, P, Naji, A, O'Connell, PJ, Greenbaum, C, Kudva, YC, Brayman, KL, Aull, MJ, Larsen, C, Kay, TWH, Fernandez, LA, Vantyghem, MC, Bellin, M & Shapiro, AMJ 2012, 'Improvement in outcomes of clinical islet transplantation: 1999-2010', Diabetes Care, vol. 35, no. 7, pp. 1436-1445. https://doi.org/10.2337/dc12-0063

@article{06aacd38e3e34d51b930652aa3691cd1,

title = "Improvement in outcomes of clinical islet transplantation: 1999-2010",

abstract = "OBJECTIVE - To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS - A total of 677 islet transplant-alone or isletafter- kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS - Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function,was retained longer in themost recent era (P",

author = "Barton, {Franca B.} and Rickels, {Michael R.} and Rodolfo Alejandro and Hering, {Bernhard J.} and Stephen Wease and Bashoo Naziruddin and Jose Oberholzer and Odorico, {Jon S.} and Garfinkel, {Marc R.} and Marlon Levy and Francois Pattou and Thierry Berney and Antonio Secchi and Shari Messinger and Senior, {Peter A.} and Paola Maffi and Andrew Posselt and Stock, {Peter G.} and Kaufman, {Dixon B.} and Xunrong Luo and Fouad Kandeel and Enrico Cagliero and Turgeon, {Nicole A.} and Piotr Witkowski and Ali Naji and O'Connell, {Philip J.} and Carla Greenbaum and Kudva, {Yogish C.} and Brayman, {Kenneth L.} and Aull, {Meredith J.} and Christian Larsen and Kay, {Tom W H} and Fernandez, {Luis A.} and Vantyghem, {Marie Christine} and Melena Bellin and Shapiro, {A. M James}",

year = "2012",

month = jul,

doi = "10.2337/dc12-0063",

language = "English",

volume = "35",

pages = "1436--1445",

journal = "Diabetes Care",

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number = "7",

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T1 - Improvement in outcomes of clinical islet transplantation

T2 - 1999-2010

AU - Barton, Franca B.

AU - Rickels, Michael R.

AU - Alejandro, Rodolfo

AU - Hering, Bernhard J.

AU - Wease, Stephen

AU - Naziruddin, Bashoo

AU - Oberholzer, Jose

AU - Odorico, Jon S.

AU - Garfinkel, Marc R.

AU - Levy, Marlon

AU - Pattou, Francois

AU - Berney, Thierry

AU - Secchi, Antonio

AU - Messinger, Shari

AU - Senior, Peter A.

AU - Maffi, Paola

AU - Posselt, Andrew

AU - Stock, Peter G.

AU - Kaufman, Dixon B.

AU - Luo, Xunrong

AU - Kandeel, Fouad

AU - Cagliero, Enrico

AU - Turgeon, Nicole A.

AU - Witkowski, Piotr

AU - Naji, Ali

AU - O'Connell, Philip J.

AU - Greenbaum, Carla

AU - Kudva, Yogish C.

AU - Brayman, Kenneth L.

AU - Aull, Meredith J.

AU - Larsen, Christian

AU - Kay, Tom W H

AU - Fernandez, Luis A.

AU - Vantyghem, Marie Christine

AU - Bellin, Melena

AU - Shapiro, A. M James

PY - 2012/7

Y1 - 2012/7

N2 - OBJECTIVE - To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS - A total of 677 islet transplant-alone or isletafter- kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS - Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function,was retained longer in themost recent era (P

AB - OBJECTIVE - To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS - A total of 677 islet transplant-alone or isletafter- kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years. RESULTS - Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002, n = 214) to 37% in the mid (2003-2006, n = 255) and to 44% in the most recent era (2007-2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function,was retained longer in themost recent era (P

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DO - 10.2337/dc12-0063

M3 - Article

C2 - 22723582

AN - SCOPUS:84862892304

SN - 1935-5548

VL - 35

SP - 1436

EP - 1445

JO - Diabetes Care

JF - Diabetes Care

IS - 7

ER -

Improvement in outcomes of clinical islet transplantation: 1999-2010

Abstract

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