TY - JOUR
T1 - Improved rheumatoid digital vasculitis in a patient treated with TNFα agent blocking (infliximab)
AU - Benucci, Maurizio
AU - Li Gobbi, Francesca
AU - Saviola, Gianantonio
AU - Manfredi, Mariangela
PY - 2008/10
Y1 - 2008/10
N2 - Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long (14 years) history of RA, who developed vasculitis of distal arteries with gangrene of digits of upper and lower extremities. After the failure of various immunosuppressive drugs (cyclophosphamide, methotrexate), the patient was treated with anti-TNFalpha infliximab. Digital gangrene healed within four months from the start of anti-TNFalpha treatment.
AB - Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long (14 years) history of RA, who developed vasculitis of distal arteries with gangrene of digits of upper and lower extremities. After the failure of various immunosuppressive drugs (cyclophosphamide, methotrexate), the patient was treated with anti-TNFalpha infliximab. Digital gangrene healed within four months from the start of anti-TNFalpha treatment.
KW - Rheumatoid vasculitis
KW - TNFα blocking agents
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U2 - 10.1007/s00296-008-0592-x
DO - 10.1007/s00296-008-0592-x
M3 - Article
C2 - 18493770
AN - SCOPUS:51649091368
SN - 0172-8172
VL - 28
SP - 1253
EP - 1255
JO - Rheumatology International
JF - Rheumatology International
IS - 12
ER -