Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation

Ken Ichiro Mizuno, Shigeki Yamazaki, Ren Iwata, Claudio Pascali, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review


On-line [11C]methylation using [11C]methyl iodide has been successfully applied to the preparation of l-[methyl-11C]-methionine (11C-Met). [11C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [11C]methylation. The present method can provide practically pure 11C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

Original languageEnglish
Pages (from-to)788-790
Number of pages3
JournalApplied Radiation and Isotopes
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Radiation


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