Importance of the presence of necrosis in studying drug distribution within tumor tissue

M. G. Donelli; M. Broggini; T. Colombo; S. Garattini

doi:10.1007/BF03189285

Importance of the presence of necrosis in studying drug distribution within tumor tissue

M. G. Donelli, M. Broggini, T. Colombo, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated. As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.

Original language	English
Pages (from-to)	63-67
Number of pages	5
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/BF03189285
Publication status	Published - Apr 1977

Keywords

Antitumoral agents
Drug distribution
Lewis Lung Carcinoma
Necrosis

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/BF03189285

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title = "Importance of the presence of necrosis in studying drug distribution within tumor tissue",

abstract = "The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated. As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.",

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author = "Donelli, {M. G.} and M. Broggini and T. Colombo and S. Garattini",

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AU - Donelli, M. G.

AU - Broggini, M.

AU - Colombo, T.

AU - Garattini, S.

PY - 1977/4

Y1 - 1977/4

N2 - The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated. As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.

AB - The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated. As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.

KW - Antitumoral agents

KW - Drug distribution

KW - Lewis Lung Carcinoma

KW - Necrosis

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ER -

Importance of the presence of necrosis in studying drug distribution within tumor tissue

Abstract

Keywords

ASJC Scopus subject areas

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