Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

D. Ribatti; B. Nico; A. Vacca

doi:10.1038/sj.onc.1209456

Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

D. Ribatti, B. Nico, A. Vacca

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.

Original language	English
Pages (from-to)	4257-4266
Number of pages	10
Journal	Oncogene
Volume	25
Issue number	31
DOIs	https://doi.org/10.1038/sj.onc.1209456
Publication status	Published - Jul 20 2006

Keywords

Angiogenesis
Bone marrow
Microenvironment
Multiple myeloma

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

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10.1038/sj.onc.1209456

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Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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